Clinical Pharmacology Fellows Publications

Mohammad Yaseen Abbasi, PhD

No current publications.

Aymin Akil, PhD

Akil AE, Rosenbaum R, Josić K. Balanced networks under spike-time dependent plasticity. PLoS Comput Biol. 2021;17(5):e1008958. Published 2021 May 12. doi:10.1371/journal.pcbi.1008958

Akil A, Bies RR, Pollock BG, et al. A population pharmacokinetic model for R- and S-citalopram and desmethylcitalopram in Alzheimer's disease patients with agitation. J Pharmacokinet Pharmacodyn. 2016;43(1):99-109. doi:10.1007/s10928-015-9457-6

Akil A, Zhang Q, Mumaw CL, et al. Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2015;21(10):1739-1745. doi 10.1016/j.bbmt.2015.07.004

Costantine Albany, MD

TBA.

Abdulateef Aregbe, MD

Aregbe AO, Sherer EA, Egorin MJ, Scher HI, Solit DB, Ramanathan RK, Ramalingam S, Belani CP, Ivy PS, Bies RR. Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors. Cancer Chemother Pharmacol. 2012 Jul. PMID: 22450873. PMCID: PMC3383947.

Blessed Winston Arul Dhas, MD

Umukoro NN, Aruldhas BW, Rossos R, Pawale D, Renschler JS, Sadhasivam S. Pharmacogenomics of oxycodone: a narrative literature review. Pharmacogenomics. 2021;22(5):275-290. doi:10.2217/pgs-2020-0143

Packiasabapathy S, Aruldhas BW, Horn N, et al. Pharmacogenomics of methadone: a narrative review of the literature. Pharmacogenomics. 2020;21(12):871-887. doi:10.2217/pgs-2020-0040

Packiasabapathy S, Zhang X, Ding L, Aruldhas BW, Pawale D, Sadhasivam S. Quantitative Pupillometry as a Predictor of Pediatric Postoperative Opioid-Induced Respiratory Depression. Anesth Analg. 2021;133(4):991-999. doi:10.1213/ANE.0000000000005579

Aruldhas BW, Quinney SK, Overholser BR, et al. Pharmacokinetic modeling of R and S-Methadone and their metabolites to study the effects of various covariates in post-operative children. CPT Pharmacometrics Syst Pharmacol. 2021;10(10):1183-1194. doi:10.1002/psp4.12687

Packiasabapathy S, Aruldhas BW, Zhang P, Overholser BR, Quinney SK, Sadhasivam S. Novel associations between CYP2B6 polymorphisms, perioperative methadone metabolism and clinical outcomes in children. Pharmacogenomics. 2021;22(10):591-602. doi:10.2217/pgs-2021-0039

Sadhasivam S, Aruldhas BW, Packiasabapathy S, et al. A Novel Perioperative Multidose Methadone-Based Multimodal Analgesic Strategy in Children Achieved Safe and Low Analgesic Blood Methadone Levels Enabling Opioid-Sparing Sustained Analgesia With Minimal Adverse Effects. Anesth Analg. 2021;133(2):327-337. doi:10.1213/ANE.0000000000005366

Alyson Baker, MD

TBA.

Nadia Bamfo, PharmD*

Bamfo NO, Hosey-Cojocari C, Benet LZ, Remsberg CM. Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans. Pharm Res. 2021 Jul;38(7):1139-1156. doi: 10.1007/s11095-021-03076-y. Epub 2021 Jul 12. PMID: 34254223.

Jason Bazil, PhD

Bazil JN, Buzzard GT, Rundell AE. Modeling mitochondrial bioenergetics with integrated volume dynamics. PLoS Comput Biol. 2010;6(1):e1000632. doi:10.1371/journal.pcbi.1000632

Lauren A. Bell, MD, MPH*

Adams ZW, Agley J, Pederson CA, Bell LA, Aalsma MC, Jackson T, Grant MT, Ott CA, Hulvershorn LA. Use of Project ECHO to promote evidence based care for justice involved adults with opioid use disorder. Subst Abus. 2022;43(1):336-343. doi: 10.1080/08897077.2021.1941518. Epub 2021 Jul 20. PMID: 34283701; PMCID: PMC8889500.

Oliver AP, Bell LA, Agley J, Bixler K, Hulvershorn LA, Adams ZW. Examining the Efficacy of Project ECHO to Improve Clinicians' Knowledge and Preparedness to Treat Adolescent Vaping. Clin Pediatr (Phila). 2022 Jun 30:99228221107816. doi: 10.1177/00099228221107816. Epub ahead of print. PMID: 35774009.

Nicole Bell, PhD

TBA.

Eric Benson, PhD, MD

Ramamoorthy A, Li L, Gaedigk A, Bradford LD, Benson EA, Flockhart DA, Skaar TC. In Silico and In Vitro Identification of MicroRNAs that Regulate HNF4A Expression. Drug Metab Dispos. 2012 Jan 9. [Epub ahead of print]. PMID: 22232426. PMCID: PMC3310421.

Benson, EA, Skaar TC. Incubation of whole blood at room temperature does not alter the plasma concentrations of microRNA-16 and -223. Drug Metab Dispos. 2013 Oct. PMID: 23886700. PMCID: PMC3781369.

Burgess KS, Philips S, Benson EA, Desta Z, Gaedigk A, Gaedigk R, Segar MW, Liu Y, Skaar TC. Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver. Clin Pharmacol Ther. 2015 Aug;98(2):205-15. PMID: 25968989; PMCID: PMC4512918.

Benson EA, Skaar TC, Liu Y, Nephew KP, Matei D. Carboplatin with Decitabine Therapy, in Recurrent Platinum Resistant Ovarian Cancer, Alters Circulating miRNAs Concentrations: A Pilot Study. PLoS One. 2015 Oct 20;10(10):e0141279. PMID: 26485143; PMCID: PMC4612782.

Eadon MT, Desta Z, Levy KD, Decker BS, Pierson RC, Pratt VM, Callaghan JT, Rosenman MB, Carpenter JS, Holmes AM, McDonald CA, Benson EA, Patil AS, Vuppalanchi R, Gufford BT, Dave N, Robarge JD, Hyder MA, Haas DM, Kreutz RP, Dexter PR, Skaar TC, Flockhart DA. Implementation of a pharmacogenomics consult service to support the INGENIOUS trial. Clin Pharmacol Ther. 2016 Jul;100(1):63-6. -Epub 2016 Mar 31. PMID: 26850569; PMCID: PMC4899152.

Benson EA, Eadon MT, Desta Z, Liu Y, Lin H, Burgess KS, Segar MW, Gaedigk A, Skaar TC. Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111. PMID: 27199754; PMCID: PMC4845040.

Eadon MT, Hause RJ, Stark AL, Cheng YH, Wheeler HE, Burgess KS, Benson EA, Cunningham PN, Bacallao RL, Dagher PC, Skaar TC, Dolan ME. Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach. Int J Mol Sci. 2017 Mar 18;18(3):661. PMID: 28335481; PMCID: PMC5372673.

Eadon MT, Cheng YH, Hato T, Benson EA, Ipe J, Collins KS, De Luca T, El- Achkar TM, Bacallao RL, Skaar TC, Dagher PC. In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice. J Drug Deliv. 2017;2017:4070793. Epub 2017 Dec 20. PMID: 29410918; PMCID: PMC5750491.

Carla Biesdorf de Almeida, PhD

Oblak AL, Cope ZA, Quinney SK, et al. Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice. Alzheimers Dement (N Y). 2022;8(1):e12317. Published 2022 Jul 14. doi:10.1002/trc2.12317

Conrado DJ, Duvvuri S, Geerts H, et al. Challenges in Alzheimer's Disease Drug Discovery and Development: The Role of Modeling, Simulation, and Open Data. Clin Pharmacol Ther. 2020;107(4):796-805. doi:10.1002/cpt.1782

Onos KD, Quinney SK, Jones DR, et al. Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL-AD preclinical testing core study. Alzheimers Dement (N Y). 2022;8(1):e12329. Published 2022 Aug 23. doi:10.1002/trc2.12329

Silvana Borges-Gonzalez, MD

Borges S, Desta Z, Jin Y, et al. Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients [published correction appears in J Clin Pharmacol. 2010 Jun;50(6):725. Philip, Santosh [corrected to Philips, Sanosh]]. J Clin Pharmacol. 2010;50(4):450-458. doi:10.1177/0091270009359182

Borges S, Li L, Hamman MA, Jones DR, Hall SD, Gorski JC. Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance. Drug Metab Dispos. 2005;33(7):1052-1055. doi:10.1124/dmd.104.003459

Borges S, Desta Z, Li L, et al. Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment. Clin Pharmacol Ther. 2006;80(1):61-74. doi:10.1016/j.clpt.2006.03.013

Li L, Borges S, Jason RD, Shen C, Desta Z, Flockhart D. A penalized mixture model approach in genotype/phenotype association analysis for quantitative phenotypes. Cancer Inform. 2010;9:93-103. Published 2010 Apr 27. doi:10.4137/cin.s3493

Josiane Cardoso

TBA.

Shripad Chitnis, PhD

Vélez de Mendizábal N, Strother RM, Farag SS, et al. Modelling the sitagliptin effect on dipeptidyl peptidase-4 activity in adults with haematological malignancies after umbilical cord blood haematopoietic cell transplantation. Clin Pharmacokinet. 2014;53(3):247-259. doi:10.1007/s40262-013-0109-y

Doo-Yeoun Cho, MD

Cho DY, Shen JH, Lemler SM, et al. Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers. Drug Metab Pharmacokinet. 2016;31(2):107-116. doi:10.1016/j.dmpk.2015.07.002

Lee H, McManus CJ, Cho DY, et al. Correction to: DNA copy number evolution in Drosophila cell lines. Genome Biol. 2019;20(1):53. Published 2019 Mar 11. doi:10.1186/s13059-019-1668-5

Lee H, Cho DY, Whitworth C, et al. Effects of Gene Dose, Chromatin, and Network Topology on Expression in Drosophila melanogaster. PLoS Genet. 2016;12(9):e1006295. Published 2016 Sep 6. doi:10.1371/journal.pgen.1006295

Cho DY, Ogburn ET, Jones D, Desta Z. Contribution of N-glucuronidation to efavirenz elimination in vivo in the basal and rifampin-induced metabolism of efavirenz. Antimicrob Agents Chemother. 2011;55(4):1504-1509. doi:10.1128/AAC.00883-10

Kimberly Collins, PhD

TBA.

Nimita Dave, PhD

Dave N, Chow LM, Gudelsky GA, LaSance K, Qi X, Desai PB. Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas. Mol Cancer Ther. 2015 Apr;14(4):857-64. doi: 10.1158/1535-7163.MCT-14-0743. PMID: 25695958. PMCID: PMC4631403.

Tom DeLuca, PhD

TBA.

Mehul G. Desai, MD

TBA.

Anh Duong, PharmD

No publications.

Noam Epstein, MD

Epstein NU, Lane KA, Farlow MR, Risacher SL, Saykin AJ, Gao S. Cognitive dysfunction and greater visit-to-visit systolic blood pressure variability. J Am Geriatr Soc. 2013;61(12):2168-2173. doi:10.1111/jgs.12542

Metzger IF, Quigg TC, Epstein N, et al. Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers. Curr Ther Res Clin Exp. 2014;76:64-69. Published 2014 Sep 27. doi:10.1016/j.curtheres.2014.05.002

Epstein NU, Saykin AJ, Risacher SL, Gao S, Farlow MR; Alzheimer's Disease Neuroimaging Initiative (ADNI). Differences in medication use in the Alzheimer's disease neuroimaging initiative: analysis of baseline characteristics. Drugs Aging. 2010;27(8):677-686. doi:10.2165/11538260-000000000-00000

Nadia Falah, MD

TBA.

Michael Ferguson, MD

TBA.

Ricardo Melo Ferreira, PhD

Melo Ferreira R, Sabo AR, Winfree S, Collins KS, Janosevic D, Gulbronson CJ, Cheng YH, Casbon L, Barwinska D, Ferkowicz MJ, Xuei X, Zhang C, Dunn KW, Kelly KJ, Sutton TA, Hato T, Dagher PC, El-Achkar TM, Eadon MT. Integration of spatial and single-cell transcriptomics localizes epithelial cell-immune cross-talk in kidney injury. JCI Insight. 2021 Jun 22;6(12):e147703. doi: 10.1172/jci.insight.147703. PMID: 34003797; PMCID: PMC8262485.

Janosevic D, Myslinski J, McCarthy TW, Zollman A, Syed F, Xuei X, Gao H, Liu YL, Collins KS, Cheng YH, Winfree S, El-Achkar TM, Maier B, Melo Ferreira R, Eadon MT, Hato T, Dagher PC. The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline. Elife. 2021 Jan 15;10:e62270. doi: 10.7554/eLife.62270. PMID: 33448928; PMCID: PMC7810465.

Melo Ferreira R, Gisch DL, Eadon MT. Spatial transcriptomics and the kidney. Curr Opin Nephrol Hypertens. 2022 May 1;31(3):244-250. doi: 10.1097/MNH.0000000000000781. Epub 2022 Feb 3. PMID: 35125393; PMCID: PMC9035033.

Eadon MT, Lampe S, Baig MM, Collins KS, Melo Ferreira R, Mang H, Cheng YH, Barwinska D, El-Achkar TM, Schwantes-An TH, Winfree S, Temm CJ, Ferkowicz MJ, Dunn KW, Kelly KJ, Sutton TA, Moe SM, Moorthi RN, Phillips CL, Dagher PC; Kidney Precision Medicine Project. Clinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans. Nephrol Dial Transplant. 2021 Dec 31;37(1):72-84. doi: 10.1093/ndt/gfaa331. PMID: 33537765; PMCID: PMC8826640.

Melo Ferreira R, Freije BJ, Eadon MT. Deconvolution Tactics and Normalization in Renal Spatial Transcriptomics. Front Physiol. 2022 Jan 13;12:812947. doi: 10.3389/fphys.2021.812947. PMID: 35095570; PMCID: PMC8793484.

Barwinska D, El-Achkar TM, Melo Ferreira R, Syed F, Cheng YH, Winfree S, Ferkowicz MJ, Hato T, Collins KS, Dunn KW, Kelly KJ, Sutton TA, Rovin BH, Parikh SV, Phillips CL, Dagher PC, Eadon MT; Kidney Precision Medicine Project. Molecular characterization of the human kidney interstitium in health and disease. Sci Adv. 2021 Feb 10;7(7):eabd3359. doi: 10.1126/sciadv.abd3359. PMID: 33568476; PMCID: PMC7875540.

Collins KS, Eadon MT, Cheng YH, Barwinska D, Melo Ferreira R, McCarthy TW, Janosevic D, Syed F, Maier B, El-Achkar TM, Kelly KJ, Phillips CL, Hato T, Sutton TA, Dagher PC. Alterations in Protein Translation and Carboxylic Acid Catabolic Processes in Diabetic Kidney Disease. Cells. 2022 Mar 30;11(7):1166. doi: 10.3390/cells11071166. PMID: 35406730; PMCID: PMC8997785.

Cathy Fulton, DNP, RN

Fulton CR, Clark C, Dickinson S. Clinical Hours in Nurse Practitioner Programs Equals Clinical Competence: Fact or Misnomer? Nurse Educ. 2017 Jul/Aug;42(4):195-198. doi: 10.1097/NNE.0000000000000346. PMID: 27922898.

Fulton CR, Swart M, De Luca T, Liu SN, Collins KS, Desta Z, Gufford BT, Eadon MT. Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness. J Nurse Pract. 2018 Nov-Dec;14(10):697-704.e1. doi: 10.1016/j.nurpra.2018.09.021. Epub 2018 Nov 2. PMID: 30555285; PMCID: PMC6291225.

Fulton CR, Zang Y, Desta Z, Rosenman MB, Holmes AM, Decker BS, Zhang Y, T Callaghan J, Pratt VM, Levy KD, Gufford BT, Dexter PR, Skaar TC, Eadon MT. Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial. Pharmacogenomics. 2019 Apr;20(6):397-408. doi: 10.2217/pgs-2018-0205. Epub 2019 Feb 20. PMID: 30784356; PMCID: PMC6562829.

Tonia Gardner Thompson, MD

TBA.

Debora Gisch, PhD

Melo Ferreira R, Gisch DL, Eadon MT. Spatial transcriptomics and the kidney. Curr Opin Nephrol Hypertens. 2022 May 1;31(3):244-250. doi: 10.1097/MNH.0000000000000781. Epub 2022 Feb 3. PMID: 35125393; PMCID: PMC9035033.

Avin KG, Hughes MC, Chen NX, Srinivasan S, O'Neill KD, Evan AP, Bacallao RL, Schulte ML, Moorthi RN, Gisch DL, Perry CGR, Moe SM, O'Connell TM. Skeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease. Sci Rep. 2021 May 7;11(1):9788. doi: 10.1038/s41598-021-89120-8. PMID: 33963215; PMCID: PMC8105324.

Ellen Go, MD

TBA.

Brandon T. Gufford, PharmD, PhD

Eadon MT, Desta Z, Levy KD, Decker BS, Pierson RC, Pratt VM, Callaghan JT, Rosenman MB, Carpenter JS, Holmes AM, McDonald CA, Benson EA, Patil AS, Vuppalanchi R, Gufford BT, Dave N, Robarge JD, Hyder MA, Haas DM, Kreutz RP, Dexter PR, Skaar TC, Flockhart DA. Implementation of a pharmacogenomics consult service to support the INGENIOUS trial. Clin Pharmacol Ther. 2016 Feb 6. doi:10.1002/cpt.347. [Epub ahead of print] Review. PMID: 26850569 PMCID: PMC4899152.

Gufford BT, Lu JB, Metzger IF, Jones DR, Desta Z. Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo. Drug Metab Dispos. 2016 Apr;44(4):544-53. Epub 2016 Jan 22. Erratum in: Drug Metab Dispos. 2016 Nov;44(11):1852. PMID: 26802129; PMCID: PMC4810769.

Andrea R. Masters, Brandon T. Gufford, Jessica Bo Li Lu, Ingrid F. Metzger, David R. Jones, and Zeruesenay Desta. Chiral plasma pharmacokinetics and urinary excretion of bupropion and metabolites in healthy volunteers. J Pharmacol Exp Ther. 2016 Aug; 358(2):230-8. PMID: 27255113. PMCID: PMC4959100. [Available on 2017-08-01]

Pierson RC, Gufford BT, Desta Z, Eadon MT. Clinical and educational impact of pharmacogenomics testing: a case series from the INGENIOUS trial. Pharmacogenomics. 2017 Jun;18(9):835-841. Epub 2017 Jun 8. PMID: 28594278; PMCID: PMC5591461.

Gufford BT, Robarge JD, Eadon MT, Gao H, Lin H, Liu Y, Desta Z, Skaar TC. Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes. Pharmacol Res Perspect. 2018 Mar 26;6(2):e00386. PMID: 29610665; PMCID: PMC5869567.

Burgess KS, Ipe J, Swart M, Metzger IF, Lu J, Gufford BT, Thong N, Desta Z, Gaedigk R, Pearce RE, Gaedigk A, Liu Y, Skaar TC. Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs. Clin Pharmacol Ther. 2018 Jul;104(1):130-138. Epub 2017 Oct 25. PMID: 28960269; PMCID: PMC5871545.

Fulton CR, Swart M, De Luca T, Liu SN, Collins KS, Desta Z, Gufford BT, Eadon MT. Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness. J Nurse Pract. 2018 Nov-Dec;14(10):697-704.e1. Epub 2018 Nov 2. PMID: 30555285; PMCID: PMC6291225.

Fulton CR, Zang Y, Desta Z, Rosenman MB, Holmes AM, Decker BS, Zhang Y, T Callaghan J, Pratt VM, Levy KD, Gufford BT, Dexter PR, Skaar TC, Eadon MT. Drug- gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial. Pharmacogenomics. 2019 Apr;20(6):397-408. Epub 2019 Feb 20. PMID: 30784356; PMCID: PMC6562829.

Liu SN, Lu JBL, Watson CJW, Lazarus P, Desta Z, Gufford BT. Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors. Drug Metab Dispos. 2019 May;47(5):535-544. Epub 2019 Feb 25. PMID: 30804050; PMCID: PMC6474910.

Liu SN, Desta Z, Gufford BT. Probenecid-Boosted Tenofovir: A Physiologically- Based Pharmacokinetic Model-Informed Strategy for On-Demand HIV Preexposure Prophylaxis. CPT Pharmacometrics Syst Pharmacol. 2020 Jan;9(1):40-47. Epub 2019 Dec 23. PMID: 31749296; PMCID: PMC6966182.

Collins KS, Metzger IF, Gufford BT, Lu JB, Medeiros EB, Pratt VM, Skaar TC, Desta Z. Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers. Drug Metab Dispos. 2020 Mar;48(3):169-175. Epub 2019 Dec 30. PMID: 31888882; PMCID: PMC7011111.

Liu SN, Gufford BT, Lu JBL, Bushman LR, Anderson PL, Bergstrom RF, Desta Z, Gupta SK. Inhibitory Effects of Probenecid on Pharmacokinetics of Tenofovir Disoproxil Fumarate and Emtricitabine for On-Demand HIV Preexposure Prophylaxis. Clin Pharmacol Ther. 2020 May;107(5):1200-1208. Epub 2019 Dec 31. PMID: 31675437; PMCID: PMC7703849

Ipe J, Li R, Metzger IF, Bo Li Lu J, Gufford BT, Desta Z, Liu Y, Skaar TC. Circulating miRNAs as Biomarkers for CYP2B6 Enzyme Activity. Clin Pharmacol Ther. 2021 Feb;109(2):485-493. Epub 2020 Oct 5. PMID: 32772362.

Abhishek Gulati, PhD

TBA.

Herbert Ho, MD

TBA.

Thang Ho, PhD

Ho T, Pollock BG, Mulsant BH, et al. R- and S-citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation. Br J Clin Pharmacol. 2016;82(3):784-792. doi:10.1111/bcp.12997

Woo Seong Huh, MD

TBA.

Jung-Won Hwang, MD, PhD

TBA.

Mustafa Hyder, MD

Eadon MT, Desta Z, levy KD, Decker BS, Pierson RC, Pratt VM, Callaghan JT, Rosenman MB, Carpenter JS, Holmes AM, McDonald CA, Benson EA, Patil AS, Vuppalanchi R, Gufford BT, Dove N, Robarge JD, Hyder MA, Gupta SK, Haas DM, Kreutz RP, Dexter PR, Skaar TC, Flockhart DA. Implementation of a pharmacogenomics consult service to support the INGENIOUS trial. Clinical Pharmacology & Therapeutics. 2016. ePub Feb G. PMID: 26850569. PMCID: PMC4899152

Chetna Jadala, PhD

No current publications.

Seongwook Jeong, MD, PHD

TBA.

Yan Jin, MD, MS*

Shi X, Xi B, Jasbi P, Turner C, Jin Y, Gu H. Comprehensive Isotopic Targeted Mass Spectrometry: Reliable Metabolic Flux Analysis with Broad Coverage. Anal Chem. 2020;92(17):11728-11738. doi:10.1021/acs.analchem.0c01767

Guo Y, Farmen MW, Jin Y, et al. Deciphering ADME genetic data using an automated haplotype approach. Pharmacogenet Genomics. 2014;24(6):292-305. doi:10.1097/FPC.0000000000000047

Jin Y, Regev A, Kam J, et al. Dose-dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor. Br J Clin Pharmacol. 2018;84(1):179-188. doi:10.1111/bcp.13423

Jin Y, Smith C, Hu L, et al. LY3127760, a Selective Prostaglandin E4 (EP4) Receptor Antagonist, and Celecoxib: A Comparison of Pharmacological Profiles. Clin Transl Sci. 2018;11(1):46-53. doi:10.1111/cts.12497

Kreutz RP, Owens J, Jin Y, et al. Cytochrome P450 3A4*22, PPAR-α, and ARNT polymorphisms and clopidogrel response. Clin Pharmacol. 2013;5:185-192. Published 2013 Dec 9. doi:10.2147/CPAA.S53151

Borges S, Desta Z, Jin Y, et al. Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients [published correction appears in J Clin Pharmacol. 2010 Jun;50(6):725. Philip, Santosh [corrected to Philips, Sanosh]]. J Clin Pharmacol. 2010;50(4):450-458. doi:10.1177/0091270009359182

Jin Y, Hayes DF, Li L, et al. Estrogen receptor genotypes influence hot flash prevalence and composite score before and after tamoxifen therapy. J Clin Oncol. 2008;26(36):5849-5854. doi:10.1200/JCO.2008.16.8377

Jin Y, Desta Z, Stearns V, et al. CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst. 2005;97(1):30-39. doi:10.1093/jnci/dji005

Murugesh Kandasamy, PhD

No current publications.

Sri Harsha Kanuri, MD, PhD, MPH

Eadon MT, Kanuri SH, Chapman AB. Pharmacogenomic studies of hypertension: paving the way for personalized antihypertensive treatment. Expert Rev Precis Med Drug Dev. 2018;3(1):33-47. doi: 10.1080/23808993.2018.1420419. Epub 2018 Jan 3. PMID: 29888336; PMCID: PMC5990020.

Levy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM, Kanuri SH, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg GS. Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med. 2019 Mar;21(3):743-747. doi: 10.1038/s41436-018-0080-y. Epub 2018 Jul 12. Erratum in: Genet Med. 2018 Aug 29; Erratum in: Genet Med. 2020 Oct;22(10):1730. Erratum in: Genet Med. 2021 Oct;23(10):2020. PMID: 29997387; PMCID: PMC6330142.

Kanuri SH, Ipe J, Kassab K, Gao H, Liu Y, Skaar TC, Kreutz RP. Next generation MicroRNA sequencing to identify coronary artery disease patients at risk of recurrent myocardial infarction. Atherosclerosis. 2018 Nov;278:232-239. doi: 10.1016/j.atherosclerosis.2018.09.021. Epub 2018 Oct 3. PMID: 30336307; PMCID: PMC6350783.

Kanuri SH, Kreutz RP. Pharmacogenomics of Novel Direct Oral Anticoagulants: Newly Identified Genes and Genetic Variants. J Pers Med. 2019 Jan 17;9(1):7. doi: 10.3390/jpm9010007. PMID: 30658513; PMCID: PMC6463033.

Levy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM, Kanuri SH, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg GS. Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med. 2019 Jul;21(7):1670. doi: 10.1038/s41436-018-0280-5. Erratum for: Genet Med. 2019 Mar;21(3):743-747. PMID: 30158693; PMCID: PMC6752260.

Levy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM, Kanuri SH, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg GS. Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med. 2020 Oct;22(10):1730. doi: 10.1038/s41436-020-0911-5. Erratum for: Genet Med. 2019 Mar;21(3):743-747. PMID: 32719393; PMCID: PMC7521989.

Levy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM, Kanuri SH, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg GS. Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med. 2021 Oct;23(10):2020. doi: 10.1038/s41436-020-01054-0. Erratum for: Genet Med. 2019 Mar;21(3):743-747. PMID: 33288881; PMCID: PMC8486650.

Kye-Min Kim, PhD

TBA.

Yangweon Kim, MD, PhD

TBA.

Lindsey Kirkpatrick, DO, PhD

TBA.

Girum L. Lemma, MD

Lemma GL, Wang Z, Hamman MA, Zaheer NA, Gorski JC, Hall SD. The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates. Clin Pharmacol Ther. 2006;79(3):218-230. doi:10.1016/j.clpt.2005.11.001

Lemma GL, Lee JW, Aisner SC, et al. Phase II study of carboplatin and paclitaxel in advanced thymoma and thymic carcinoma. J Clin Oncol. 2011;29(15):2060-2065. doi:10.1200/JCO.2010.32.9607

Maayan Leroy-Melamed, MD, MPH

Leroy-Melamed M, Katz A, Shew ML. Menstrual Dysfunction and Treatment Among Adolescents With Congenital Heart Disease. J Pediatr Adolesc Gynecol. 2020 Dec;33(6):686-690. doi: 10.1016/j.jpag.2020.08.012. Epub 2020 Aug 20. PMID: 32827759.

Leroy-Melamed M, Zhao Q, Belmonte MA, Archer J, Peipert JF. Contraceptive Preference, Continuation Rates, and Unintended Pregnancies in Patients with Comorbidities: A Prospective Cohort Study. J Womens Health (Larchmt). 2021 Oct;30(10):1469-1475. doi: 10.1089/jwh.2020.8536. Epub 2021 Jan 6. PMID: 33404367; PMCID: PMC8590153.

Leroy-Melamed M, Jacob S, Shew ML, Kazmerski TM. Provider Attitudes, Preferences, and Practices Regarding Sexual and Reproductive Health for Adolescents and Young Adults With Sickle Cell Disease. J Adolesc Health. 2021 Dec;69(6):970-975. doi: 10.1016/j.jadohealth.2021.06.008. Epub 2021 Jul 20. PMID: 34294508; PMCID: PMC8612941.

Youngchai Lim, PhD

Lim YC, Li L, Desta Z, et al. Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J Pharmacol Exp Ther. 2006;318(2):503-512. doi:10.1124/jpet.105.100511

Lim YC, Desta Z, Flockhart DA, Skaar TC. Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen. Cancer Chemother Pharmacol. 2005;55(5):471-478. doi:10.1007/s00280-004-0926-7

Stephanie Liu, PharmD

Fulton CR, Swart M, De Luca T, Liu SN, Collins KS, Desta Z, Gufford BT, Eadon MT. Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness. J Nurse Pract. 2018 Nov-Dec;14(10):697-704.e1. doi: 10.1016/j.nurpra.2018.09.021. Epub 2018 Nov 2. PMID: 30555285; PMCID: PMC6291225.

Liu SN, Lu JBL, Watson CJW, Lazarus P, Desta Z, Gufford BT. Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors. Drug Metab Dispos. 2019 May;47(5):535-544. doi: 10.1124/dmd.118.085035. Epub 2019 Feb 25. PMID: 30804050; PMCID: PMC6474910.

Liu SN, Desta Z, Gufford BT. Probenecid-Boosted Tenofovir: A Physiologically-Based Pharmacokinetic Model-Informed Strategy for On-Demand HIV Preexposure Prophylaxis. CPT Pharmacometrics Syst Pharmacol. 2020 Jan;9(1):40-47. doi: 10.1002/psp4.12481. Epub 2019 Dec 23. PMID: 31749296; PMCID: PMC6966182.

Liu SN, Gufford BT, Lu JBL, Bushman LR, Anderson PL, Bergstrom RF, Desta Z, Gupta SK. Inhibitory Effects of Probenecid on Pharmacokinetics of Tenofovir Disoproxil Fumarate and Emtricitabine for On-Demand HIV Preexposure Prophylaxis. Clin Pharmacol Ther. 2020 May;107(5):1200-1208. doi: 10.1002/cpt.1714. Epub 2019 Dec 31. PMID: 31675437; PMCID: PMC7703849.

Deshun Lu, PhD

Kreutz RP, Breall JA, Kreutz Y, Owens J, Lu D, Bolad I, von der Lohe E, Sinha A, Flockhart DA. Protease activated receptor-1 (PAR-1) mediated platelet aggregation is dependent on clopidogrel response. Thromb Res. 2012 Aug. PMID: 22459907. PMCID: PMC3965578.

Kreutz RP, Owens J, Breall JA, Lu D, von der Lohe E, Bolad I, Sinha A, Flockhart DA. C-reactive protein and fibrin clot strength measured by thrombelastography after coronary stenting. 2013 Apr. PMID: 23429252. PMCID: PMC4028117.

Lv W, Liu J, Lu D, Flockhart DA, Cushman M. Synthesis of mixed (E, Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities. J Med Chem. 2013 Jun. PMID 23731360. PMCID: PMC4043309.

Lu D, Owens J, Kreutz RP. Plasma and whole blood clot strength measured by thrombelastography in patients treated with clopidogrel during acute coronary syndromes. Thromb Res. 2013 Aug. PMID: 23920429. PMCID: PMC4028119.

Liu, J, Flockhart PJ, Lu D, Lv W, Lu WJ, Han x, Cushman M, Flockhart DA. Inhibition of cytochrome p450 enzymes by the e- and z-isomers of norendoxifen. Drug Metab Dispos. 2013 Sep. PMID: 23824607. PMCID: PMC3876808.

Reynold Ly, PhD

TBA.

Srikar Malireddy, MD*

Quinney SK, Malireddy SR, Vuppalanchi R, Hamman MA, Chalasani N, Gorski JC, Hall SD. Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin. Eur J Clin Pharmacol. 2013 Mar;69(3):439-48. doi: 10.1007/s00228-012-1339-x. Epub 2012 Jul 10. PMID: 22777148; PMCID: PMC3712509.

Chiorean EG, Malireddy S, Younger AE, Jones DR, Waddell MJ, Sloop MI, Yu M, Hall SD, Schneider B, Sweeney CJ. A phase I dose escalation and pharmacokinetic study of vatalanib (PTK787/ZK 222584) in combination with paclitaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2010 Aug;66(3):441-8. doi: 10.1007/s00280-009-1179-2. Epub 2009 Nov 29. PMID: 20091169.

Malireddy SR, Pinto AG, Chalasani NP, Gorski JC, Hall SD. Altered first-pass effects in a liver transplant recipient explained intraindividual variation in calcineurin inhibitor concentrations: a case report. Transplant Proc. 2008 Jun;40(5):1789-91. doi: 10.1016/j.transproceed.2008.02.073. PMID: 18589198.

Tarunendu Mapder, PharmD*

Browning AP, Sharp JA, Mapder T, Baker CM, Burrage K, Simpson MJ. Persistence as an Optimal Hedging Strategy. Biophys J. 2021 Jan 5;120(1):133-142. doi: 10.1016/j.bpj.2020.11.2260. Epub 2020 Nov 28. PMID: 33253635; PMCID: PMC7820789.

Roy C, Mandal SM, Mondal SK, Mukherjee S, Mapder T, Ghosh W, Chakraborty R. Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus. Genomics. 2020 Nov;112(6):5331-5342. doi: 10.1016/j.ygeno.2020.11.003. Epub 2020 Nov 5. PMID: 33161087; PMCID: PMC7644180.

Ferrari Gianlupi J, Mapder T, Sego TJ, Sluka JP, Quinney SK, Craig M, Stratford RE Jr, Glazier JA. Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2. Viruses. 2022 Mar 14;14(3):605. doi: 10.3390/v14030605. PMID: 35337012; PMCID: PMC8953050.

Smith Marri, MD*

Mwangi SM, Nezami BG, Obukwelu B, Anitha M, Marri S, Fu P, Epperson MF, Le NA, Shanmugam M, Sitaraman SV, Tseng YH, Anania FA, Srinivasan S. Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity. Am J Physiol Gastrointest Liver Physiol. 2014 Mar;306(6):G515-25. doi: 10.1152/ajpgi.00364.2013. PMID: 24458024. PMCID: PMC3949027.

Harrison SA, Marri SR, Chalasani N, et al. Randomised clinical study: GR-MD-02, a galectin-3 inhibitor in patients having nonalcoholic steatohepatitis with advanced fibrosis. Aliment Pharmacol Ther. 2016 Dec;44(11-12):1183-1198. doi: 10.1111/apt.13816. Epub 2016 Oct 24. PMID: 27778367.

Emily Mason, PhD

Mason ER, Wu F, Patel RR, Xiao Y, Cannon SC, Cummins TR. Resurgent and Gating Pore Currents Induced by De Novo SCN2A Epilepsy Mutations. eNeuro. 2019 Oct 16;6(5):ENEURO.0141-19.2019. doi: 10.1523/ENEURO.0141-19.2019. PMID: 31558572; PMCID: PMC6795554.

Mason ER, Cummins TR. Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967. Int J Mol Sci. 2020 Apr 1;21(7):2454. doi: 10.3390/ijms21072454. PMID: 32244818; PMCID: PMC7177867.

Potjewyd FM, Annor-Gyamfi JK, Aubé J, Chu S, Conlon IL, Frankowski KJ, Guduru SKR, Hardy BP, Hopkins MD, Kinoshita C, Kireev DB, Mason ER, Moerk CT, Nwogbo F, Pearce KH Jr, Richardson TI, Rogers DA, Soni DM, Stashko M, Wang X, Wells C, Willson TM, Frye SV, Young JE, Axtman AD. Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology. Alzheimers Dement (N Y). 2022 Apr 12;8(1):e12253. doi: 10.1002/trc2.12253. PMID: 35434254; PMCID: PMC9005681.

Potjewyd FM, Annor-Gyamfi JK, Aubé J, Chu S, Conlon IL, Frankowski KJ, Guduru SKR, Hardy BP, Hopkins MD, Kinoshita C, Kireev DB, Mason ER, Moerk CT, Nwogbo F, Pearce KH, Richardson TI, Rogers DA, Soni DM, Stashko M, Wang X, Wells C, Willson TM, Frye SV, Young JE, Axtman AD. AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery. Alzheimers Dement (N Y). 2022 Apr 20;8(1):e12246. doi: 10.1002/trc2.12246. PMID: 35475262; PMCID: PMC9019904.

Darius Meiman, PharmD*

McNamara PJ, Meiman D. Predicting Drug Binding to Human Serum Albumin and Alpha One Acid Glycoprotein in Diseased and Age Patient Populations. J Pharm Sci. 2019 Aug;108(8):2737-2747. doi: 10.1016/j.xphs.2019.03.018. Epub 2019 Mar 21. PMID: 30905706.

Ingrid Ferreira Metzger, PhD

TBA.

Jia Miao, MD

TBA.

Veronique Michaud, PhD, MSc

TBA.

Nick Miles, PharmD*

Tillman EM, Suppes SL, Miles N, Duty AM, Kelley KL, Goldman JL. Risks and mitigation strategies to prevent etoposide infusion-related reactions in children. Pharmacotherapy. 2021 Aug;41(8):700-706. doi: 10.1002/phar.2603. Epub 2021 Jun 29. PMID: 34129705; PMCID: PMC8617599.

Kathleen A. Neville, MD

Bawa S, Brooks DS, Neville KE, et al. Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth. Elife. 2020;9:e52358. Published 2020 Mar 30. doi:10.7554/eLife.52358

Tremoulet A, Le J, Poindexter B, et al. Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design. Antimicrob Agents Chemother. 2014;58(6):3013-3020. doi:10.1128/AAC.02374-13

Atluri S, Neville K, Davis M, et al. Epstein-Barr-associated leiomyomatosis and T-cell chimerism after haploidentical bone marrow transplantation for severe combined immunodeficiency disease. J Pediatr Hematol Oncol. 2007;29(3):166-172. doi:10.1097/MPH.0b013e31803b95b3

Nseobong Ntukidem, MD

Ntukidem NI, Nguyen AT, Stearns V, et al. Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen. Clin Pharmacol Ther. 2008;83(5):702-710. doi:10.1038/sj.clpt.6100343

Aislinn O'Kane, PharmD*

No current publications.

Chimnonso Onuoha, PharmD*

Garner MP, Onuoha CP, Fenn NE 3rd. Low-Molecular-Weight Heparin and Fondaparinux Use in Pediatric Patients With Obesity. Ann Pharmacother. 2021 May;55(5):666-676. doi: 10.1177/1060028020955029. Epub 2020 Aug 30. PMID: 32864984.

Onuoha CP, Garner MP, Fenn NE 3rd. Student perceptions of co-curricular activities on pharmacy education: A review. Curr Pharm Teach Learn. 2021 May;13(5):576-584. doi: 10.1016/j.cptl.2021.01.017. Epub 2021 Feb 24. PMID: 33795114.

Rebecca Pierson, MD*

Pierson, RC, Gordon SS, and Haas DM. A retrospective comparison of antibiotic regimens for preterm premature rupture of membranes. Obstetrics and Gynecology. 2014. 124(3):515-19. PMID: 25162251. PMCID: PMC4147675.

Eadon MT, Desta Z, Levy KD, Decker BS, Pierson RC, Pratt VM, Callaghan JT, Rosenman MB, Carpenter JS, Holmes AM, McDonald CA, Benson EA, Patil AS, Vuppalanchi R, Gufford BT, Dave N, Robarge JD, Hyder MA, Haas DM, Kreutz RP, Dexter PR, Skaar TC, Flockhart DA. Implementation of a pharmacogenomics consult service to support the INGENIOUS trial. Clin Pharmacol Ther. 2016 Jul;100(1):63-6. doi: 10.1002/cpt.347. Epub 2016 Mar 31. PMID: 26850569; PMCID: PMC4899152.

Pierson RC, Gordon SS, Haas DM. A retrospective comparison of antibiotic regimens for preterm premature rupture of membranes. Obstet Gynecol. 2014 Sep;124(3):515-519. doi: 10.1097/AOG.0000000000000426. PMID: 25162251; PMCID: PMC4147675.

Pierson RC, Malone AM, Haas DM. Increasing Influenza Vaccination Rates in a Busy Urban Clinic. J Nat Sci. 2015;1(3):e57. PMID: 25750936; PMCID: PMC4347981.

Amar Pinto, MD

TBA.

Jagdeep (JD) Podichetty, PhD

Podichetty JT, Silvola RM, Rodriguez-Romero V, et al. Application of machine learning to predict reduction in total PANSS score and enrich enrollment in schizophrenia clinical trials. Clin Transl Sci. 2021;14(5):1864-1874. doi:10.1111/cts.13035

Podichetty JT, Brinda BJ, Nelson RP, et al. Pharmacokinetics of Basiliximab for the Prevention of Graft-versus-Host Disease in Patients Undergoing Hematopoietic Cell Transplantation with Minimal-Intensity Cyclophosphamide and Fludarabine. Pharmacotherapy. 2020;40(1):26-32. doi:10.1002/phar.2347

Nick Powell, PharmD*

Powell NR, Zhao H, Ipe J, Liu Y, Skaar TC. Mapping the miRNA-mRNA Interactome in Human Hepatocytes and Identification of Functional mirSNPs in Pharmacogenes. Clin Pharmacol Ther. 2021 Oct;110(4):1106-1118. doi: 10.1002/cpt.2379. Epub 2021 Aug 13. PMID: 34314509; PMCID: PMC9007393.

Powell NR, Shugg T, Ly RC, Albany C, Radovich M, Schneider BP, Skaar TC. Life-Threatening Docetaxel Toxicity in a Patient With Reduced-Function CYP3A Variants: A Case Report. Front Oncol. 2022 Jan 31;11:809527. doi: 10.3389/fonc.2021.809527. PMID: 35174070; PMCID: PMC8841796.

Troy Quigg, MD*

Metzger IF, Quigg TC, Epstein N, Aregbe AO, Thong N, Callaghan JT, Flockhart DA, Nguyen AT, Stevens CK, Gupta SK, Desta Z. Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers. Curr Ther Res Clin Exp. 2014 Sep 27;76:64-9. doi: 10.1016/j.curtheres.2014.05.002. PMID: 25352936; PMCID: PMC4209507.

Michaud V, Ogburn E, Thong N, Aregbe AO, Quigg TC, Flockhart DA, Desta Z. Induction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteers. Clin Pharmacol Ther. 2012 Mar;91(3):475-82. doi: 10.1038/clpt.2011.249. Epub 2012 Feb 8. PMID: 22318618; PMCID: PMC3667659.

Quigg TC, Mahajerin A, Sullivan PD, Pradhan K, Bauer NS. Ages and Stages Questionnaires-3 developmental screening of infants and young children with cancer. J Pediatr Oncol Nurs. 2013 Sep-Oct;30(5):235-41. doi: 10.1177/1043454213493510. Epub 2013 Jul 18. PMID: 23867965; PMCID: PMC4026287.

Quigg TC, Kim YJ, Goebel WS, Haut PR. Lung function before and after pediatric allogeneic hematopoietic stem cell transplantation: a predictive role for DLCOa/VA. J Pediatr Hematol Oncol. 2012 May;34(4):304-9. doi: 10.1097/MPH.0b013e3182346ed8. PMID: 22246156; PMCID: PMC4019990.

Quigg TC, Haddad NG, Buchsbaum JC, Shih CS. Hypothalamic obesity syndrome: rare presentation of CNS+ B-cell lymphoblastic lymphoma. Pediatr Blood Cancer. 2012 Nov;59(5):930-3. doi: 10.1002/pbc.24058. Epub 2011 Dec 27. PMID: 22213612; PMCID: PMC4020003.

Sara Quinney, PharmD, PhD*

Shanks AL, Grasch JL, Quinney SK, Haas DM. Controversies in antenatal corticosteroids. Semin Fetal Neonatal Med. 2019 Jun;24(3):182-188. doi: 10.1016/j.siny.2019.05.002. Epub 2019 May 29. PMID: 31155465 Review.

Quinney SK, Bonate PL. A pharmacometrician's role in enhancing medication use in pregnancy and lactation. J Pharmacokinet Pharmacodyn. 2020 Aug;47(4):267-269. doi: 10.1007/s10928-020-09707-y. PMID: 32803462 Free PMC article. No abstract available.

Aruldhas BW, Quinney SK, Overholser BR, Heathman MA, Masters AR, Ly RC, Gao H, Packiasabapathy S, Sadhasivam S. Pharmacokinetic modeling of R and S-Methadone and their metabolites to study the effects of various covariates in post-operative children. CPT Pharmacometrics Syst Pharmacol. 2021 Oct;10(10):1183-1194. doi: 10.1002/psp4.12687. Epub 2021 Aug 26. PMID: 34435753 Free PMC article.

Packiasabapathy S, Aruldhas BW, Horn N, Overholser BR, Quinney SK, Renschler JS, Sadhasivam S. Pharmacogenomics of methadone: a narrative review of the literature. Pharmacogenomics. 2020 Aug;21(12):871-887. doi: 10.2217/pgs-2020-0040. Epub 2020 Jul 24. PMID: 32705966 Free PMC article. Review.

Wu HY, Shendre A, Zhang S, Zhang P, Wang L, Zeruesenay D, Rocha LM, Shatkay H, Quinney SK, Ning X, Li L. Translational Knowledge Discovery Between Drug Interactions and Pharmacogenetics. Clin Pharmacol Ther. 2020 Apr;107(4):886-902. doi: 10.1002/cpt.1745. Epub 2020 Feb 3. PMID: 31863452 Free PMC article. Review.

Liao MZ, Flood Nichols SK, Ahmed M, Clark S, Hankins GD, Caritis S, Venkataramanan R, Haas D, Quinney SK, Haneline LS, Tita AT, Manuck T, Wang J, Thummel KE, Brown LM, Ren Z, Easterling TR, Hebert MF. Effects of Pregnancy on the Pharmacokinetics of Metformin. Drug Metab Dispos. 2020 Apr;48(4):264-271. doi: 10.1124/dmd.119.088435. Epub 2020 Jan 24. PMID: 31980499 Free PMC article. Clinical Trial.

Quinney SK, Gullapelli R, Haas DM. Translational Systems Pharmacology Studies in Pregnant Women. CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):69-81. doi: 10.1002/psp4.12269. Epub 2017 Dec 14. PMID: 29239132 Free PMC article. Review.

Metzger IF, Thomas AE, Evrard CA, Jones DR, Masters AR, Haas DM, Haneline LS, Quinney SK. Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome. Am J Perinatol. 2021 Jul;38(9):968-975. doi: 10.1055/s-0040-1701505. Epub 2020 Feb 12. PMID: 32052397

Quinney SK, Patil AS, Flockhart DA. Is personalized medicine achievable in obstetrics? Semin Perinatol. 2014 Dec;38(8):534-40. doi: 10.1053/j.semperi.2014.08.017. Epub 2014 Oct 3. PMID: 25282474 Free PMC article. Review.

Sorkin BC, Kuszak AJ, Bloss G, Fukagawa NK, Hoffman FA, Jafari M, Barrett B, Brown PN, Bushman FD, Casper SJ, Chilton FH, Coffey CS, Ferruzzi MG, Hopp DC, Kiely M, Lakens D, MacMillan JB, Meltzer DO, Pahor M, Paul J, Pritchett-Corning K, Quinney SK, Rehermann B, Setchell KDR, Sipes NS, Stephens JM, Taylor DL, Tiriac H, Walters MA, Xi D, Zappalá G, Pauli GF. Improving natural product research translation: From source to clinical trial. FASEB J. 2020 Jan;34(1):41-65. doi: 10.1096/fj.201902143R. Epub 2019 Dec 10. PMID: 31914647 Free PMC article.

Marks C, Silvola R, Teal E, Quinney SK, Haas DM. Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study. Pharmacotherapy. 2021 Nov;41(11):907-914. doi: 10.1002/phar.2628. Epub 2021 Oct 26. PMID: 34587291

Sukoff Rizzo SJ, Masters A, Onos KD, Quinney S, Sasner M, Oblak A, Lamb BT, Territo PR; MODEL‐AD consortium. Improving preclinical to clinical translation in Alzheimer's disease research. Alzheimers Dement (N Y). 2020 Jun 14;6(1):e12038. doi: 10.1002/trc2.12038. eCollection 2020. PMID: 32548237 Free PMC article.

McKinzie AH, Yang Z, Teal E, Daggy JK, Tepper RS, Quinney SK, Rhoads E, Haneline LS, Haas DM. Are newborn outcomes different for term babies who were exposed to antenatal corticosteroids? Am J Obstet Gynecol. 2021 Nov;225(5):536.e1-536.e7. doi: 10.1016/j.ajog.2021.04.251. Epub 2021 May 3. PMID: 33957112

Yao X, Tsang T, Sun Q, Quinney S, Zhang P, Ning X, Li L, Shen L. Mining and visualizing high-order directional drug interaction effects using the FAERS database. BMC Med Inform Decis Mak. 2020 Mar 18;20(Suppl 2):50. doi: 10.1186/s12911-020-1053-z. PMID: 32183790 Free PMC article.

Packiasabapathy S, Aruldhas BW, Zhang P, Overholser BR, Quinney SK, Sadhasivam S. Novel associations between CYP2B6 polymorphisms, perioperative methadone metabolism and clinical outcomes in children. Pharmacogenomics. 2021 Jul;22(10):591-602. doi: 10.2217/pgs-2021-0039. Epub 2021 Jun 8. PMID: 34100292 Free PMC article.

Zhang P, Wu HY, Chiang CW, Wang L, Binkheder S, Wang X, Zeng D, Quinney SK, Li L. Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research. CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):90-102. doi: 10.1002/psp4.12267. Epub 2018 Jan 9. PMID: 29193890 Free PMC article. Review.

Quinney SK, Benjamin T, Zheng X, Patil AS. Characterization of Maternal and Fetal CYP3A-Mediated Progesterone Metabolism. Fetal Pediatr Pathol. 2017 Oct;36(5):400-411. doi:10.1080/15513815.2017.1354411. Epub 2017 Sep 26.PMID: 28949811 Free PMC article.

Kinney MT, Quinney SK, Trussell HK, Silva LL, Ibrahim SA, Haas DM. Do maternal demographics and prenatal history impact the efficacy of betamethasone therapy for threatened preterm labor? BMC Pregnancy Childbirth. 2021 Jun 24;21(1):442. doi: 10.1186/s12884-021-03949-5. PMID: 34167497 Free PMC article.

Sadhasivam S, Aruldhas BW, Packiasabapathy S, Overholser BR, Zhang P, Zang Y, Renschler JS, Fitzgerald RE, Quinney SK. A Novel Perioperative Multidose Methadone-Based Multimodal Analgesic Strategy in Children Achieved Safe and Low Analgesic Blood Methadone Levels Enabling Opioid-Sparing Sustained Analgesia With Minimal Adverse Effects. Anesth Analg. 2021 Aug 1;133(2):327-337. doi:10.1213/ANE.0000000000005366.PMID: 33481403 Free PMC article. Clinical Trial.

Caan BJ, Meyerhardt JA, Brown JC, Campbell KL, Cespedes Feliciano EM, Lee C, Ross MC, Quinney S, Quesenberry C, Sternfeld B, Schmitz KH. Recruitment strategies and design considerations in a trial of resistance training to prevent dose-limiting toxicities in colon cancer patients undergoing chemotherapy. Contemp Clin Trials. 2021 Feb;101:106242. doi: 10.1016/j.cct.2020.106242. Epub 2020 Dec 7. PMID: 33301991 Free PMC article. Clinical Trial.

Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, Brown LM, Ren Z, Brown Z, Easterling TR, Hebert MF. Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus.Clin Pharmacol Ther. 2020 Jun;107(6):1362-1372. doi: 10.1002/cpt.1749. Epub 2020 Jan 25.PMID: 31869430 Free PMC article. Clinical Trial.

Haas DM, Benjamin T, Sawyer R, Quinney SK. Short-term tocolytics for preterm delivery - current perspectives.Int J Womens Health. 2014 Mar 27;6:343-9. doi: 10.2147/IJWH.S44048. eCollection 2014. PMID: 24707187 Free PMC article. Review.

Hua L, Chiang CW, Cong W, Li J, Wang X, Cheng L, Feng W, Quinney SK, Wang L, Li L. The Cancer Drug Fraction of Metabolism Database. CPT Pharmacometrics Syst Pharmacol. 2019 Jul;8(7):511-519. doi: 10.1002/psp4.12417. Epub 2019 Jun 17. PMID: 31206254 Free PMC article.

Wang X, Zhang P, Chiang CW, Wu H, Shen L, Ning X, Zeng D, Wang L, Quinney SK, Feng W, Li L. Mixture drug-count response model for the high-dimensional drug combinatory effect on myopathy. Stat Med. 2018 Feb 20;37(4):673-686. doi: 10.1002/sim.7545. Epub 2017 Nov 23. PMID: 29171062 Free PMC article.

McDowell ML, Tonismae TR, Slaven JE, Abernathy MP, Shanks AL, Benjamin TD, Quinney SK. The Impact of Hepatitis C Virus Infection on Buprenorphine Dose in Pregnancy. Am J Perinatol. 2020 Jan;37(1):73-78. doi: 10.1055/s-0039-1698838. Epub 2019 Oct 26. PMID: 31655490

Quinney SK, Haehner BD, Rhoades MB, Lin Z, Gorski JC, Hall SD. Interaction between midazolam and clarithromycin in the elderly. Br J Clin Pharmacol. 2008 Jan;65(1):98-109. doi: 10.1111/j.1365-2125.2007.02970.x. Epub 2007 Jul 17. PMID: 17635500 Free PMC article. Clinical Trial.

Friedman AN, Considine RV, Quinney SK. Inquiry into the short- and long-term effects of Roux-en-Y gastric bypass on the glomerular filtration rate. Ren Fail. 2020 Nov;42(1):624-628. doi: 10.1080/0886022X.2020.1790389.PMID: 32654577 Free PMC article.

Wu HY, Karnik S, Subhadarshini A, Wang Z, Philips S, Han X, Chiang C, Liu L, Boustani M, Rocha LM, Quinney SK, Flockhart D, Li L. An integrated pharmacokinetics ontology and corpus for text mining.BMC Bioinformatics. 2013 Feb 1;14:35. doi: 10.1186/1471-2105-14-35.PMID: 23374886 Free PMC article.

Friedman AN, Moe S, Fadel WF, Inman M, Mattar SG, Shihabi Z, Quinney SK. Predicting the glomerular filtration rate in bariatric surgery patients. Am J Nephrol. 2014;39(1):8-15. doi: 10.1159/000357231. Epub 2013 Dec 19. PMID: 24356416 Free PMC article.

Wu HY, Lu D, Hyder M, Zhang S, Quinney SK, Desta Z, Li L. DrugMetab: An Integrated Machine Learning and Lexicon Mapping Named Entity Recognition Method for Drug Metabolite. CPT Pharmacometrics Syst Pharmacol. 2018 Nov;7(11):709-717. doi: 10.1002/psp4.12340. Epub 2018 Sep 29. PMID: 30033622 Free PMC article.

Chiang CW, Zhang P, Wang X, Wang L, Zhang S, Ning X, Shen L, Quinney SK, Li L. Translational High-Dimensional Drug Interaction Discovery and Validation Using Health Record Databases and Pharmacokinetics Models. Clin Pharmacol Ther. 2018 Feb;103(2):287-295. doi: 10.1002/cpt.914. Epub 2017 Dec 11. PMID: 29052226

Miao J, Jin Y, Marunde RL, Gorski CJ, Kim S, Quinney S, Radovich M, Li L, Hall SD. Association of genotypes of the CYP3A cluster with midazolam disposition in vivo. Pharmacogenomics J. 2009 Oct;9(5):319-26. doi: 10.1038/tpj.2009.21. Epub 2009 Jun 9. PMID: 19506580 Free PMC article.

Quinney SK, Malireddy SR, Vuppalanchi R, Hamman MA, Chalasani N, Gorski JC, Hall SD. Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin. Eur J Clin Pharmacol. 2013 Mar;69(3):439-48. doi: 10.1007/s00228-012-1339-x. Epub 2012 Jul 10. PMID: 22777148 Free PMC article. Clinical Trial.

Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, Morris Brown L, Ren Z, Brown Z, Easterling TR, Hebert MF. Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus. J Clin Pharmacol. 2020 Apr;60(4):540-549. doi: 10.1002/jcph.1549. Epub 2019 Nov 19. PMID: 31742716 Free PMC article. Clinical Trial.

Oblak AL, Cope ZA, Quinney SK, Pandey RS, Biesdorf C, Masters AR, Onos KD, Haynes L, Keezer KJ, Meyer JA, Peters JS, Persohn SA, Bedwell AA, Eldridge K, Speedy R, Little G, Williams SP, Noarbe B, Obenaus A, Sasner M, Howell GR, Carter GW, Williams H, Lamb BT, Territo PR, Sukoff Rizzo SJ. Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice. Alzheimers Dement (N Y). 2022 Jul 14;8(1):e12317. doi: 10.1002/trc2.12317. eCollection 2022. PMID: 35846156 Free PMC article.

Dorr ML, Pierson RC, Daggy J, Quinney SK, Haas DM. Buccal versus Vaginal Misoprostol for Term Induction of Labor: A Retrospective Cohort Study. Am J Perinatol. 2019 Jun;36(7):765-772. doi: 10.1055/s-0038-1675219. Epub 2018 Oct 31. PMID: 30380580 Free PMC article.

Podichetty JT, Brinda BJ, Nelson RP, Karr AH, Prasad NK, Quinney S, Foxworthy Scott S, Kiel PJ. Pharmacokinetics of Basiliximab for the Prevention of Graft-versus-Host Disease in Patients Undergoing Hematopoietic Cell Transplantation with Minimal-Intensity Cyclophosphamide and Fludarabine. Pharmacotherapy. 2020 Jan;40(1):26-32. doi: 10.1002/phar.2347. Epub 2019 Dec 20. PMID: 31742732 Clinical Trial.

Quinney SK. Opportunities and Challenges of Using Big Data to Detect Drug-Drug Interaction Risk. Clin Pharmacol Ther. 2019 Jul;106(1):72-74. doi: 10.1002/cpt.1481. Epub 2019 Jun 11. PMID: 31184772 Free PMC article. No abstract available.

Haas DM, Daggy J, Flannery KM, Dorr ML, Bonsack C, Bhamidipalli SS, Pierson RC, Lathrop A, Towns R, Ngo N, Head A, Morgan S, Quinney SK. A comparison of vaginal versus buccal misoprostol for cervical ripening in women for labor induction at term (the IMPROVE trial): a triple-masked randomized controlled trial. Am J Obstet Gynecol. 2019 Sep;221(3):259.e1-259.e16. doi: 10.1016/j.ajog.2019.04.037. Epub 2019 May 7. PMID: 31075246 Free PMC article. Clinical Trial.

Zhang X, Galinsky RE, Kimura RE, Quinney SK, Jones DR, Hall SD. Inhibition of CYP3A by erythromycin: in vitro-in vivo correlation in rats. Drug Metab Dispos. 2010 Jan;38(1):61-72. doi: 0.1124/dmd.109.028290. PMID: 19797607

Haas DM, Quinney SK, Clay JM, Renbarger JL, Hebert MF, Clark S, Umans JG, Caritis SN; Obstetric-Fetal Pharmacology Research Units Network. Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic. Am J Perinatol. 2013 Apr;30(4):275-81. doi: 10.1055/s-0032-1323590. Epub 2012 Aug 8. PMID: 22875663 Free PMC article.

Quinney SK, Zhang X, Lucksiri A, Gorski JC, Li L, Hall SD. Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin. Drug Metab Dispos. 2010 Feb;38(2):241-8. doi: 10.1124/dmd.109.028746. Epub 2009 Nov 2. PMID: 19884323 Free PMC article.

Silva LL, Silvola RM, Haas DM, Quinney SK. Physiologically based pharmacokinetic modelling in pregnancy: Model reproducibility and external validation. Br J Clin Pharmacol. 2022 Feb;88(4):1441-1451. doi: 10.1111/bcp.15018. Epub 2021 Aug 26. PMID: 34337764

Blue EK, Ballman K, Boyle F, Oh E, Kono T, Quinney SK, Thurmond DC, Evans-Molina C, Haneline LS. Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats. Pediatr Res. 2015 Feb;77(2):316-25. doi: 10.1038/pr.2014.185. Epub 2014 Nov 20. PMID: 25412163 Free PMC article.

Zhang P, Li M, Chiang CW, Wang L, Xiang Y, Cheng L, Feng W, Schleyer TK, Quinney SK, Wu HY, Zeng D, Li L. Three-Component Mixture Model-Based Adverse Drug Event Signal Detection for the Adverse Event Reporting System. CPT Pharmacometrics Syst Pharmacol. 2018 Aug;7(8):499-506. doi:0.1002/psp4.12294. Epub 2018 Aug 9. PMID: 30091855 Free PMC article.

Zhang X, Quinney SK, Gorski JC, Jones DR, Hall SD. Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite. Drug Metab Dispos. 2009 Aug;37(8):1587-97. doi: 10.1124/dmd.109.026658. Epub 2009 May 6. PMID: 19420129 Clinical Trial.

Friedman AN, Strother M, Quinney SK, Hall S, Perkins SM, Brizendine EJ, Inman M, Gomez G, Shihabi Z, Moe S, Li L. Measuring the glomerular filtration rate in obese individuals without overt kidney disease. Nephron Clin Pract. 2010;116(3):c224-34. doi: 10.1159/000317203. Epub 2010 Jul 2. PMID: 20606483 Free PMC article. Clinical Trial.

Binkheder S, Wu HY, Quinney SK, Zhang S, Zitu MM, Chiang CW, Wang L, Jones J, Li L. PhenoDEF: a corpus for annotating sentences with information of phenotype definitions in biomedical literature. J Biomed Semantics. 2022 Jun 11;13(1):17. doi: 10.1186/s13326-022-00272-6. PMID: 35690873 Free PMC article.

Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab Dispos. 2004 May;32(5):505-11. doi: 10.1124/dmd.32.5.505. PMID: 15100172

Towns R, Quinney SK, Pierson RC, Haas DM. Survey of Provider Preferences Regarding the Route of Misoprostol for Induction of Labor at Term. AJP Rep. 2017 Jul;7(3):e158-e162. doi: 10.1055/s-0037-1603954. Epub 2017 Jul 25. PMID: 28752015 Free PMC article.

Duke JD, Han X, Wang Z, Subhadarshini A, Karnik SD, Li X, Hall SD, Jin Y, Callaghan JT, Overhage MJ, Flockhart DA, Strother RM, Quinney SK, Li L. Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions. PLoS Comput Biol. 2012;8(8):e1002614. doi: 10.1371/journal.pcbi.1002614. Epub 2012 Aug 9. PMID: 22912565 Free PMC article.

Han X, Quinney SK, Wang Z, Zhang P, Duke J, Desta Z, Elmendorf JS, Flockhart DA, Li L. Identification and Mechanistic Investigation of Drug-Drug Interactions Associated With Myopathy: A Translational Approach. Clin Pharmacol Ther. 2015 Sep;98(3):321-7. doi: 10.1002/cpt.150. PMID: 25975815 Free PMC article.

Friedman AN, Quinney SK, Inman M, Mattar SG, Shihabi Z, Moe S. Influence of dietary protein on glomerular filtration before and after bariatric surgery: a cohort study. Am J Kidney Dis. 2014 Apr;63(4):598-603. doi: 10.1053/j.ajkd.2013.11.012. Epub 2013 Dec 31. PMID: 24387796 Free PMC article.

Friedman AN, Yu Z, Juliar BE, Nguyen JT, Strother M, Quinney SK, Li L, Inman M, Gomez G, Shihabi Z, Moe S. Independent influence of dietary protein on markers of kidney function and disease in obesity. Kidney Int. 2010 Oct;78(7):693-7. doi: 10.1038/ki.2010.184. Epub 2010 Jul 21. PMID: 20664561 Clinical Trial.

Blue EK, DiGiuseppe R, Derr-Yellin E, Acosta JC, Pay SL, Hanenberg H, Schellinger MM, Quinney SK, Mund JA, Case J, Haneline LS. Gestational diabetes induces alterations in the function of neonatal endothelial colony-forming cells. Pediatr Res. 2014 Feb;75(2):266-72. doi: 10.1038/pr.2013.224. Epub 2013 Nov 14. PMID: 24232636 Free PMC article.

Ferrari Gianlupi J, Mapder T, Sego TJ, Sluka JP, Quinney SK, Craig M, Stratford RE Jr, Glazier JA. Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2. Viruses. 2022 Mar 14;14(3):605. doi: 10.3390/v14030605. PMID: 35337012 Free PMC article.

Vorontsova Y, Haas DM, Flannery K, Masters AR, Silva LL, Pierson RC, Yeley B, Hogg G, Guise D, Heathman M, Quinney SK. Pharmacokinetics of vaginal versus buccal misoprostol for labor induction at term. Clin Transl Sci. 2022 May 19. doi: 10.1111/cts.13306. Online ahead of print. PMID: 35587540

Sanghani SP, Quinney SK, Fredenburg TB, Sun Z, Davis WI, Murry DJ, Cummings OW, Seitz DE, Bosron WF. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. Clin Cancer Res. 2003 Oct 15;9(13):4983-91. PMID: 14581373

Du L, Chakraborty A, Chiang CW, Cheng L, Quinney SK, Wu H, Zhang P, Li L, Shen L. Graphic Mining of High-Order Drug Interactions and Their Directional Effects on Myopathy Using Electronic Medical Records. CPT Pharmacometrics Syst Pharmacol. 2015 Aug;4(8):481-8. doi: 10.1002/psp4.59. Epub 2015 Jul 6. PMID: 26380157 Free PMC article.

Egbelakin A, Ferguson MJ, MacGill EA, Lehmann AS, Topletz AR, Quinney SK, Li L, McCammack KC, Hall SD, Renbarger JL. Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2011 Mar;56(3):361-7. doi: 10.1002/pbc.22845. Epub 2010 Nov 11. PMID: 21225912 Free PMC article.

Haas DM, Quinney SK, McCormick CL, Jones DR, Renbarger JL. A pilot study of the impact of genotype on nifedipine pharmacokinetics when used as a tocolytic. J Matern Fetal Neonatal Med. 2012 Apr;25(4):419-23. doi: 10.3109/14767058.2011.583700. Epub 2011 Jun 7. PMID: 21644845 Clinical Trial.

Quinney SK, Galinsky RE, Jiyamapa-Serna VA, Chen Y, Hamman MA, Hall SD, Kimura RE. Hydroxyitraconazole, formed during intestinal first-pass metabolism of itraconazole, controls the time course of hepatic CYP3A inhibition and the bioavailability of itraconazole in rats. Drug Metab Dispos. 2008 Jun;36(6):1097-101. doi: 10.1124/dmd.108.020644. Epub 2008 Mar 13. PMID: 18339815

Wang L, Chiang C, Liang H, Wu H, Feng W, Quinney SK, Li J, Li L. How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective. Biomed Res Int. 2015;2015:857327. doi: 10.1155/2015/857327. Epub 2015 Oct 11. PMID: 26539530 Free PMC article.

Wang Z, Kim S, Quinney SK, Guo Y, Hall SD, Rocha LM, Li L. Literature mining on pharmacokinetics numerical data: a feasibility study. J Biomed Inform. 2009 Aug;42(4):726-35. doi: 10.1016/j.jbi.2009.03.010. Epub 2009 Apr 2. PMID: 19345282 Free PMC article.

Quinney SK, Knopp S, Chang C, Hall SD, Li L. Integration of in vitro binding mechanism into the semiphysiologically based pharmacokinetic interaction model between ketoconazole and midazolam. CPT Pharmacometrics Syst Pharmacol. 2013 Sep 11;2(9):e75. doi: 10.1038/psp.2013.50. PMID: 24448021 Free PMC article.

Xu C, Quinney SK, Guo Y, Hall SD, Li L, Desta Z. CYP2B6 pharmacogenetics-based in vitro-in vivo extrapolation of efavirenz clearance by physiologically based pharmacokinetic modeling. Drug Metab Dispos. 2013 Dec;41(12):2004-11. doi: 10.1124/dmd.113.051755. Epub 2013 Jul 11. PMID: 23846872 Free PMC article. Clinical Trial.

Zhang P, Du L, Wang L, Liu M, Cheng L, Chiang CW, Wu HY, Quinney SK, Shen L, Li L. A Mixture Dose-Response Model for Identifying High-Dimensional Drug Interaction Effects on Myopathy Using Electronic Medical Record Databases. CPT Pharmacometrics Syst Pharmacol. 2015 Aug;4(8):474-80. doi: 10.1002/psp4.53. Epub 2015 Jul 6. PMID: 26380156 Free PMC article.

Quinney SK, Mohamed AN, Hebert MF, Haas DM, Clark S, Umans JG, Caritis SN, Li L. A Semi-Mechanistic Metabolism Model of CYP3A Substrates in Pregnancy: Predicting Changes in Midazolam and Nifedipine Pharmacokinetics. CPT Pharmacometrics Syst Pharmacol. 2012 Sep 26;1(9):e2. doi: 10.1038/psp.2012.5. PMID: 23835882 Free PMC article.

Nader AM, Quinney SK, Fadda HM, Foster DR. Effect of Gastric Fluid Volume on the In Vitro Dissolution and In Vivo Absorption of BCS Class II Drugs: a Case Study with Nifedipine. AAPS J. 2016 Jul;18(4):981-8. doi: 10.1208/s12248-016-9918-x. Epub 2016 Apr 22. PMID: 27106837 Free PMC article.

Wang Z, Kim S, Quinney SK, Zhou J, Li L. Non-compartment model to compartment model pharmacokinetics transformation meta-analysis--a multivariate nonlinear mixed model. BMC Syst Biol. 2010 May 28;4 Suppl 1(Suppl 1):S8. doi: 10.1186/1752-0509-4-S1-S8. PMID: 20522258 Free PMC article.

Osteen SJ, Yang Z, Mckinzie AH, Teal E, Tepper RS, Rhoads E, Quinney SK, Haneline LS, Haas DM. Long-term childhood outcomes for babies born at term who were exposed to antenatal corticosteroids. Am J Obstet Gynecol. 2022 Jul 21:S0002-9378(22)00580-4. doi: 10.1016/j.ajog.2022.07.026. Online ahead of print. PMID: 35872037

Binkheder S, Wu HY, Quinney SK, Zhang S, Zitu MM, Chiang CW, Wang L, Jones J, Li L. Correction: PhenoDEF: a corpus for annotating sentences with information of phenotype definitions in biomedical literature. J Biomed Semantics. 2022 Jul 20;13(1):20. doi: 10.1186/s13326-022-00275-3. PMID: 35858945 Free PMC article. No abstract available.

Anthony Raviele, PharmD*

Collins KS, Raviele ALJ, Elchynski AL, Woodcock AM, Zhao Y, Cooper-DeHoff RM, Eadon MT. Genotype-Guided Hydralazine Therapy. Am J Nephrol. 2020;51(10):764-776. doi: 10.1159/000510433. Epub 2020 Sep 14. PMID: 32927458; PMCID: PMC7606720.

Jason Robarge, PhD*

Eadon MT, Desta Z, Levy KD, Decker BS, Pierson RC, Pratt VM, Callaghan JT, Rosenman MB, Carpenter JS, Holmes AM, McDonald CA, Benson EA, Patil AS, Vuppalanchi R, Gufford BT, Dave N, Robarge JD, Hyder MA, Haas DM, Kreutz RP, Dexter PR, Skaar TC, Flockhart DA. Implementation of a pharmacogenomics consult service to support the INGENIOUS trial. Clin Pharmacol Ther. 2016 Feb 6. doi:10.1002/cpt.347. [Epub ahead of print] Review. PMID: 26850569 PMCID: PMC4899152

Santa-Maria CA, Blackford A, Nguyen AT, Skaar TC, Philips S, Oesterreich S, Rae JM, Desta Z, Robarge J, Henry NL, Storniolo AM, Hayes DF, Blumenthal RS, Ouyang P, Post WS, Flockhart DA, Stearns V;. Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy. Clin Cancer Res 2016 Mar 15;22(6):1395-402. PMID: 26463708. PMCID: PMC4794377.

Robarge JD, Duarte DB, Shariati 3, Wang 4, Flockhart D5, Vasko MR. Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons. Exp Neural. 2016 April 9; 281: 53-65. PMID: 27072527. PMCID: PMC4877294.

Eadon MT, Desta Z, Levy KD, Decker BS, Pierson RC, Pratt VM, Callaghan JT, Rosenman MB, Carpenter JS, Holmes AM, McDonald CA, Benson EA, Patil AS, Vuppalanchi R, Gufford BT, Dave N, Robarge JD, Hyder MA, Haas DM, Kreutz RP, Dexter PR, Skaar TC, Flockhart DA. Implementation of a pharmacogenomics consult service to support the INGENIOUS trial. Clin Pharmacol Ther. 2016 Jul;100(1):63-6. PMID: 26850569. PMCID: PMC4899152.

Abdelhady AM, Shugg T, Thong N, Lu JB, Kreutz Y, Jaynes HA, Robarge JD, Tisdale JE, Desta Z, Overholser BR. Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6*6*6 Allele Carriers. J Cardiovasc Electrophysiol. 2016 Oct;27(10):1206-1213Epub 2016 Jul 25. PMID: 27333947; PMCID: PMC5065384.

Robarge JD, Metzger IF, Lu J, Thong N, Skaar TC, Desta Z, Bies RR. Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition. Antimicrob Agents Chemother. 2016 Dec 27;61(1):e01813-16PMID: 27799204; PMCID: PMC5192152.

Robarge JD, Desta Z, Nguyen AT, Li L, Hertz D, Rae JM, Hayes DF, Storniolo AM, Stearns V, Flockhart DA, Skaar TC, Henry NL. Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer. Breast Cancer Res Treat. 2017 Feb;161(3):453-461. Epub 2016 Dec 9. PMID: 27943008; PMCID: PMC5429096.

Violeta Rodriguez Romero, PhD

TBA.

Elizabeth Rowe, PhD

Tuteja S, Salloum RG, Elchynski AL, Smith DM, Rowe E, Blake KV, Limdi NA, Aquilante CL, Bates J, Beitelshees AL, Cipriani A, Duong BQ, Empey PE, Formea CM, Hicks JK, Mroz P, Oslin D, Pasternak AL, Petry N, Ramsey LB, Schlichte A, Swain SM, Ward KM, Wiisanen K, Skaar TC, Van Driest SL, Cavallari LH, Bishop JR; IGNITE Pharmacogenetics Working Group. Multisite evaluation of institutional processes and implementation determinants for pharmacogenetic testing to guide antidepressant therapy. Clin Transl Sci. 2022 Feb;15(2):371-383. doi: 10.1111/cts.13154. Epub 2021 Sep 25. PMID: 34562070; PMCID: PMC8841452.

Shugg T, Ly RC, Rowe EJ, Philips S, Hyder MA, Radovich M, Rosenman MB, Pratt VM, Callaghan JT, Desta Z, Schneider BP, Skaar TC. Clinical Opportunities for Germline Pharmacogenetics and Management of Drug-Drug Interactions in Patients With Advanced Solid Cancers. JCO Precis Oncol. 2022 Feb;6:e2100312. doi: 10.1200/PO.21.00312. PMID: 35201852.

Salloum RG, Bishop JR, Elchynski AL, Smith DM, Rowe E, Blake KV, Limdi NA, Aquilante CL, Bates J, Beitelshees AL, Cipriani A, Duong BQ, Empey PE, Formea CM, Hicks JK, Mroz P, Oslin D, Pasternak AL, Petry N, Ramsey LB, Schlichte A, Swain SM, Ward KM, Wiisanen K, Skaar TC, Van Driest SL, Cavallari LH, Tuteja S. Best-worst scaling methodology to evaluate constructs of the Consolidated Framework for Implementation Research: application to the implementation of pharmacogenetic testing for antidepressant therapy. Implement Sci Commun. 2022 May 14;3(1):52. doi: 10.1186/s43058-022-00300-7. PMID: 35568931; PMCID: PMC9107643.

Oliver Schantz, MD

Ho T, Pollock BG, Mulsant BH, et al. R- and S-citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation. Br J Clin Pharmacol. 2016;82(3):784-792. doi:10.1111/bcp.12997

Anna Schwartz, MD

TBA.

Eric Sherer, PhD

TBA.

Tyler Shugg, PharmD, PhD

Ly RC, Shugg T, Ratcliff R, Osei W, Lynnes TC, Pratt VM, Schneider BP, Radovich M, Bray SM, Salisbury BA, Parikh B, Sahinalp SC, Numanagić I, Skaar TC. Analytical Validation of a Computational Method for Pharmacogenetic Genotyping from Clinical Whole Exome Sequencing. J Mol Diagn. 2022 Jun;24(6):576-585. doi: 10.1016/j.jmoldx.2022.03.008. Epub 2022 Apr 20. PMID: 35452844; PMCID: PMC9227988.

Shugg T, Ly RC, Rowe EJ, Philips S, Hyder MA, Radovich M, Rosenman MB, Pratt VM, Callaghan JT, Desta Z, Schneider BP, Skaar TC. Clinical Opportunities for Germline Pharmacogenetics and Management of Drug-Drug Interactions in Patients With Advanced Solid Cancers. JCO Precis Oncol. 2022 Feb;6:e2100312. doi: 10.1200/PO.21.00312. PMID: 35201852.

Powell NR, Shugg T, Ly RC, Albany C, Radovich M, Schneider BP, Skaar TC. Life-Threatening Docetaxel Toxicity in a Patient With Reduced-Function CYP3A Variants: A Case Report. Front Oncol. 2022 Jan 31;11:809527. doi: 10.3389/fonc.2021.809527. PMID: 35174070; PMCID: PMC8841796.

Shugg T, Pasternak AL, Luzum JA. Comparison of clinical pharmacogenetic recommendations across therapeutic areas. Pharmacogenet Genomics. 2022 Feb 1;32(2):51-59. doi: 10.1097/FPC.0000000000000452. PMID: 34412102; PMCID: PMC8702450.

Shugg T, Pasternak AL, London B, Luzum JA. Prevalence and types of inconsistencies in clinical pharmacogenetic recommendations among major U.S. sources. NPJ Genom Med. 2020 Oct 30;5:48. doi: 10.1038/s41525-020-00156-7. PMID: 33145028; PMCID: PMC7603298.

Shugg T, Dave N, Amarh E, Assiri AA, Pollok KE, Overholser BR. Letrozole targets the human ether-a-go-go-related gene potassium current in glioblastoma. Basic Clin Pharmacol Toxicol. 2021 Mar;128(3):357-365. doi: 10.1111/bcpt.13515. Epub 2020 Oct 27. PMID: 33040444; PMCID: PMC7889647.

Shugg T, Hudmon A, Overholser BR. Neurohormonal Regulation of I_Ks in Heart Failure: Implications for Ventricular Arrhythmogenesis and Sudden Cardiac Death. J Am Heart Assoc. 2020 Sep 15;9(18):e016900. doi: 10.1161/JAHA.120.016900. Epub 2020 Aug 31. PMID: 32865116; PMCID: PMC7726975.

Shugg T, Somberg JC, Molnar J, Overholser BR. Inhibition of Human Ether-A-Go-Go-Related Gene (hERG) Potassium Current by the Novel Sotalol Analogue, Soestalol. JACC Clin Electrophysiol. 2020 Jul;6(7):756-759. doi: 10.1016/j.jacep.2020.05.037. PMID: 32703555.

Shugg T, Egly C, Stamatkin CW, Patil AS, Tisdale JE, Overholser BR. Progesterone Metabolites Inhibit the Human Ether-a-go-go-Related Gene and Predict QT Interval Length. J Clin Pharmacol. 2019 Dec 12. doi: 10.1002/jcph.1563. Epub ahead of print. PMID: 31829451.

Luzum JA, Ting C, Peterson EL, Gui H, Shugg T, Williams LK, Li L, Sadee W, Wang D, Lanfear DE. Association of Regulatory Genetic Variants for Protein Kinase Cα with Mortality and Drug Efficacy in Patients with Heart Failure. Cardiovasc Drugs Ther. 2019 Dec;33(6):693-700. doi: 10.1007/s10557-019-06909-6. PMID: 31728800; PMCID: PMC7197488.

Shugg T, Johnson DE, Shao M, Lai X, Witzmann F, Cummins TR, Rubart-Von-der Lohe M, Hudmon A, Overholser BR. Calcium/calmodulin-dependent protein kinase II regulation of I_Ks during sustained β-adrenergic receptor stimulation. Heart Rhythm. 2018 Jun;15(6):895-904. doi: 10.1016/j.hrthm.2018.01.024. Epub 2018 Feb 2. PMID: 29410121; PMCID: PMC5984714.

Abdelhady AM, Shugg T, Thong N, Lu JB, Kreutz Y, Jaynes HA, Robarge JD, Tisdale JE, Desta Z, Overholser BR. Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6*6*6 Allele Carriers. J Cardiovasc Electrophysiol. 2016 Oct;27(10):1206-1213. doi: 10.1111/jce.13032. Epub 2016 Jul 25. PMID: 27333947; PMCID: PMC5065384.

Xu P, Bajaj G, Shugg T, Van Alstine WG, Yeo Y. Zwitterionic chitosan derivatives for pH-sensitive stealth coating. Biomacromolecules. 2010 Sep 13;11(9):2352-8. doi: 10.1021/bm100481r. PMID: 20695636; PMCID: PMC2941802.

Elizabeth Sierra Potchanant, PhD

TBA.

Larissa Silva, PharmD

Kinney MT, Quinney SK, Trussell HK, Silva LL, Ibrahim SA, Haas DM. Do maternal demographics and prenatal history impact the efficacy of betamethasone therapy for threatened preterm labor? BMC Pregnancy Childbirth. 2021 Jun 24;21(1):442. doi: 10.1186/s12884-021-03949-5. PMID: 34167497; PMCID: PMC8228510.

Silva LL, Silvola RM, Haas DM, Quinney SK. Physiologically based pharmacokinetic modelling in pregnancy: Model reproducibility and external validation. Br J Clin Pharmacol. 2022 Feb;88(4):1441-1451. doi: 10.1111/bcp.15018. Epub 2021 Aug 26. PMID: 34337764.

Vorontsova Y, Haas DM, Flannery K, Masters AR, Silva LL, Pierson RC, Yeley B, Hogg G, Guise D, Heathman M, Quinney SK. Pharmacokinetics of vaginal versus buccal misoprostol for labor induction at term. Clin Transl Sci. 2022 May 19. doi: 10.1111/cts.13306. Epub ahead of print. PMID: 35587540.

Rebecca Silvola, PharmD*

Marks C, Silvola R, Teal E, Quinney SK, Haas DM. Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study. Pharmacotherapy. 2021 Nov;41(11):907-914. doi: 10.1002/phar.2628. Epub 2021 Oct 26. PMID: 34587291; PMCID: PMC8608752.

Podichetty JT, Silvola RM, Rodriguez-Romero V, Bergstrom RF, Vakilynejad M, Bies RR, Stratford RE Jr. Application of machine learning to predict reduction in total PANSS score and enrich enrollment in schizophrenia clinical trials. Clin Transl Sci. 2021 Sep;14(5):1864-1874. doi: 10.1111/cts.13035. Epub 2021 May 3. PMID: 33939284; PMCID: PMC8504834.

Silva LL, Silvola RM, Haas DM, Quinney SK. Physiologically based pharmacokinetic modelling in pregnancy: Model reproducibility and external validation. Br J Clin Pharmacol. 2022 Feb;88(4):1441-1451. doi: 10.1111/bcp.15018. Epub 2021 Aug 26. PMID: 34337764.

Jasper Stevens, PhD

TBA.

Matthew Strother, MD*

Busakhala NW, Waako PJ, Strother MR, Keter AK, Kigen GK, Asirwa FC, Loehrer PJ. Randomized Phase IIA Trial of Gemcitabine Compared With Bleomycin Plus Vincristine for Treatment of Kaposi's Sarcoma in Patients on Combination Antiretroviral Therapy in Western Kenya. J Glob Oncol. 2018 Sep;4:1-9. doi: 10.1200/JGO.17.00077. PMID: 30241150; PMCID: PMC6223418.

Khozaim K, Orang'o E, Christoffersen-Deb A, Itsura P, Oguda J, Muliro H, Ndiema J, Mwangi G, Strother M, Cu-Uvin S, Rosen B, Washington S. Successes and challenges of establishing a cervical cancer screening and treatment program in western Kenya. Int J Gynaecol Obstet. 2014 Jan;124(1):12-8. doi: 10.1016/j.ijgo.2013.06.035. Epub 2013 Sep 25. PMID: 24140218.

Friedman AN, Strother M, Quinney SK, Hall S, Perkins SM, Brizendine EJ, Inman M, Gomez G, Shihabi Z, Moe S, Li L. Measuring the glomerular filtration rate in obese individuals without overt kidney disease. Nephron Clin Pract. 2010;116(3):c224-34. doi: 10.1159/000317203. Epub 2010 Jul 2. PMID: 20606483; PMCID: PMC2945276.

Friedman AN, Yu Z, Juliar BE, Nguyen JT, Strother M, Quinney SK, Li L, Inman M, Gomez G, Shihabi Z, Moe S. Independent influence of dietary protein on markers of kidney function and disease in obesity. Kidney Int. 2010 Oct;78(7):693-7. doi: 10.1038/ki.2010.184. Epub 2010 Jul 21. PMID: 20664561.

Gerald So, PharmD*

No current publications.

Toru Takahaski, MD, PhD

None.

Irin Tanaudommongkon, PharmD*

None.

Alicia Teagarden, DO

TBA.

David Thacker, PharmD*

Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, El Rouby N, Johnson JA, Cavallari LH, Shakhnovich V, Thacker DL, Scott SA, Schwab M, Uppugunduri CRS, Formea CM, Franciosi JP, Sangkuhl K, Gaedigk A, Klein TE, Gammal RS, Furuta T. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing. Clin Pharmacol Ther. 2021 Jun;109(6):1417-1423. doi: 10.1002/cpt.2015. Epub 2020 Sep 20. PMID: 32770672; PMCID: PMC7868475.

Thacker DL, Modak A, Flockhart DA, Desta Z. Is (+)-[13C]-pantoprazole better than (±)-[13C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity? J Breath Res. 2013 Mar;7(1):016001. doi: 10.1088/1752-7155/7/1/016001. Epub 2012 Dec 21. PMID: 23257668; PMCID: PMC3587180.

Thacker DL, Modak A, Nguyen PD, Flockhart DA, Desta Z. Stereoselective pharmacokinetics of stable isotope (+/-)-[13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity. Chirality. 2011 Nov;23(10):904-9. doi: 10.1002/chir.21011. Epub 2011 Sep 20. PMID: 21935988; PMCID: PMC4409653.

Michelle Torres, MD*

None.

Nieves Velez de Mendizabal, PhD

TBA.

Yana Voronstova, PharmD*

Vorontsova Y, Haas DM, Flannery K, et al. Pharmacokinetics of vaginal versus buccal misoprostol for labor induction at term. Clin Transl Sci. 2022;15(8):1937-1945. doi:10.1111/cts.13306

Alette Wessels, PhD

Mintun MA, Lo AC, Duggan Evans C, et al. Donanemab in Early Alzheimer's Disease. N Engl J Med. 2021;384(18):1691-1704. doi:10.1056/NEJMoa2100708

Wessels AM, Edgar CJ, Nathan PJ, Siemers ER, Maruff P, Harrison J. Cognitive Go/No-Go decision-making criteria in Alzheimer's disease drug development. Drug Discov Today. 2021;26(5):1330-1336. doi:10.1016/j.drudis.2021.01.012

Wessels AM, Tariot PN, Zimmer JA, et al. Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials [published correction appears in JAMA Neurol. 2020 Sep 1;77(9):1179]. JAMA Neurol. 2020;77(2):199-209. doi:10.1001/jamaneurol.2019.3988

Rentz DM, Wessels AM, Annapragada AV, et al. Building clinically relevant outcomes across the Alzheimer's disease spectrum. Alzheimers Dement (N Y). 2021;7(1):e12181. Published 2021 Jun 26. doi:10.1002/trc2.12181

Zimmer JA, Shcherbinin S, Devous MD Sr, et al. Lanabecestat: Neuroimaging results in early symptomatic Alzheimer's disease. Alzheimers Dement (N Y). 2021;7(1):e12123. Published 2021 Feb 14. doi:10.1002/trc2.12123

Wessels AM, Lines C, Stern RA, et al. Cognitive outcomes in trials of two BACE inhibitors in Alzheimer's disease. Alzheimers Dement. 2020;16(11):1483-1492. doi:10.1002/alz.12164

Wessels AM, Lane KA, Gao S, Hall KS, Unverzagt FW, Hendrie HC. Diabetes and cognitive decline in elderly African Americans: a 15-year follow-up study. Alzheimers Dement. 2011;7(4):418-424. doi:10.1016/j.jalz.2010.07.003

Wessels AM, Rentz DM, Case M, Lauzon S, Sims JR. Integrated Alzheimer's Disease Rating Scale: Clinically meaningful change estimates. Alzheimers Dement (N Y). 2022;8(1):e12312. Published 2022 Jun 6. doi:10.1002/trc2.12312

Liu-Seifert H, Andersen S, Case M, et al. Statistical properties of continuous composite scales and implications for drug development. J Biopharm Stat. 2017;27(6):1104-1114. doi:10.1080/10543406.2017.1315819

Rentz DM, Wessels AM, Bain LJ, Weber CJ, Carrillo MC. Clinical meaningfulness addressed at Alzheimer's Association Research Roundtable. Alzheimers Dement. 2020;16(5):814. doi:10.1002/alz.12111

Wessels AM, Jin Y, Pollock BG, et al. Adherence to escitalopram treatment in depression: a study of electronically compiled dosing histories in the 'Depression: the search for phenotypes' study. Int Clin Psychopharmacol. 2012;27(6):291-297. doi:10.1097/YIC.0b013e3283597678

Wessels AM, Bies RR, Pollock BG, et al. Population pharmacokinetic modeling of ziprasidone in patients with schizophrenia from the CATIE study. J Clin Pharmacol. 2011;51(11):1587-1591. doi:10.1177/0091270010387604

Jacob Zucker, MD

TBA.